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TOPIC 356: FLUOROGENIC ASSAY PLATFORM FOR CIRCULAR RNA DETECTION

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 75N91019C00046
Agency Tracking Number: N44CA190046
Amount: $1,480,983.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: NCI
Solicitation Number: N/A
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
760 Parkside Avenue, Suite 327B
Brooklyn, NY 11226-1787
United States
DUNS: 961919508
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Balajee Somalinga
 (214) 458-7019
 balajee.somalinga@lucernatechnologies.com
Business Contact
 Balajee Somalinga
Phone: (214) 458-7019
Email: balajee.somalinga@lucernatechnologies.com
Research Institution
N/A
Abstract

Circular RNAscircRNAsare a novel class of modified RNAs that are an abundant component of the epitranscriptomePutative functions of circRNAsinclude miRNA sequestrationRNA binding protein scaffoldingmRNA trappingand protein translation regulationDeregulation in one or more of these roles has been linked to several types of cancerOne well studied circRNAciRSis believed to act as a miRNAsponge and inhibit its regulation of oncogenic receptors and tumor suppressor factorsDespite all the excitement around circRNAsmany of the recently discovered circRNAs remain poorly understood and progress has been extremely slowAn important reason is the lack of accessible tools to allow for the mechanistic study of individual circRNARecognizing this unmet needa simple fluorogenic assay platform to detect circRNAs of interest in biochemical and cell lysate based samples is proposedIn this Phase II projectthe development of the ciRSassays for biochemical and cell based application will be finalizedFurthera robust standard operating procedure to streamline future custom circRNA development will be establishedLastlyassay benchmarks and distribution conditions for production scale up will be determinedUpon completionthe circRNA sensor platform would find commercial applications in circRNA researchdrug discoveryand biomarker development

* Information listed above is at the time of submission. *

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