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TOPIC 368: TREATMENT OPTIMIZATION BY COMBINED A-EMITTER (ARPT)/RADIOTHERAPY (XRT) DOSIMETRY FOR PROSTATE CANCER PATIENTS

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 75N91019C00040
Agency Tracking Number: N44CA190040
Amount: $1,999,796.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: NCI
Solicitation Number: N/A
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1800 GOUGH ST
BALTIMORE, MD 21231-2607
United States
DUNS: 080200015
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Michael Ghaly
 (443) 524-7396
 mghaly@rapiddosimetry.com
Business Contact
 Michael Ghaly
Phone: (443) 524-7396
Email: mghaly@rapiddosimetry.com
Research Institution
N/A
Abstract

We propose to demonstrate a cloud based software service for Combination alpha emitter radiopharmaceutical therapyRPTand external beam radiotherapyXRTCX RPTtreatment planningBoth modalities deliver radiationWe will demonstrate feasibility clinically by collecting the data needed from an existing Hopkins trial evaluating combination XRT with XofigoRa dichlorideanRPT that concentratesparticle radiation to prostate cancer bone metastasesBypiggybackingon this trial we will evaluate the dosimetry technology for CX RPT that we propose to develop and commercialize without having to cover the costs of the entire trialObjectiveVia the studies proposed and data collecteddemonstrateretrospectivelythatof the patients would have benefitted from an adjustment in their XRT treatment plan to meet tumor dose criteria while respecting organ dose constraintsObjectiveImplement the CX RPT enabling softwareD RD Xin a web cloud system as a prototype for a future software service add on to existingD XRT treatment planning systemsObjectiveValidateD RD X against RPTDoseour Phase I proof of concept prototypeThe work proposed will enable a treatment planning based combination treatment of XRT andRPT using cloud based softwareThis will improve patient care by reducing the empiricism typical of chemo XRT combination therapy and demonstrate the efficacy of a cloud based system for performing the treatment planning

* Information listed above is at the time of submission. *

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