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TOPIC 359: A DEVICE PROTOTYPE FOR ISOLATION OF MELANOMA EXOSOMES FOR DIAGNOSTICS AND TREATMENT MONITORING

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 75N91019C00042
Agency Tracking Number: N44CA190042
Amount: $1,860,561.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: NCI
Solicitation Number: N/A
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
3030 BUNKER HILL ST, #4000
SAN DIEGO, CA 92109-5757
United States
DUNS: 054460865
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Annette Marleau
 (858) 997-9435
 annette@aethlonmedical.com
Business Contact
 Annette Marleau
Phone: (858) 997-9435
Email: annette@aethlonmedical.com
Research Institution
N/A
Abstract

The proposed work aims to develop a pre commercial prototype of an exosome isolation device to be used in clinical diagnostic laboratoriesWe will advance the device to facilitate exosome isolation for downstream liquid biopsy tests requiring analysis of proteinDNAor microRNAwhich rely upon acquisition of intact and pure exosomesThe device strategy will be designed to isolate total exosomes and then to separate discrete populations of tumor derived exosomesTEXand non malignant exosomesnon TEXThe device strategy will be advanced for melanoma exosome isolation in the proposed experiments but is expected to be applicable for other cancersTo achieve this study s objectiveswe will develop and optimize a filtration system incorporating the GNA Hemopurifier for isolation of total exosomes from biofluidsSpecific AimThe capabilities of the GNA Hemopurifier for isolating melanoma TEX and non TEX from diverse biofluids will be characterized by evaluating exosome depletion performanceSpecific AimWe will then construct a novel devicethe CSPGcartridgefor the isolation of TEX from total exosomesfollowed by testing the final workflow from the starting biofluid sample to the final TEX isolationSpecific AimSuccessful completion of this project will produce an exosome isolation system that will be applicable for high throughput exosome isolation and for TEX and non TEX separation from diverse biofluids of varying complexity in a clinical care setting in oncology

* Information listed above is at the time of submission. *

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