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SBIR PHASE I TOPIC 392: TARGETED RADIONUCLIDE THERAPY OF METASTATIC LIVER CANCER: PATIENT SPECIFIC OPTIMIZATION

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 75N91019C00047
Agency Tracking Number: N43CA190047
Amount: $299,275.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: NCI
Solicitation Number: N/A
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1800 GOUGH ST
BALTIMORE, MD 21231-2607
United States
DUNS: 080200015
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Michael Ghaly
 (443) 470-0824
 mghaly@rapiddosimetry.com
Business Contact
 Michael Ghaly
Phone: (443) 470-0824
Email: mghaly@rapiddosimetry.com
Research Institution
N/A
Abstract

Radioembolization using Ymicrospheres delivered into the hepatic artery under fluoroscopy guidance has slowed tumor progression in the liver for patients diagnosed with metastatic colorectal cancermCRCTreatment planning is based on a simple estimate of the average absorbed doseADdelivered to the treated volumetumor dose thus depends on tumor burden and tumor to background ratioresulting in under dosing in some patientsDosing based on more rigorouspatient specific AD to normal liver would allow safely increasing administered activitylikely improving tumor responsewithout an increased toxicityThe goal of this work is to improve the outcome of patients with mCRC by implementing a cloud based treatment planning software service using rigorous quantitative imaging and dosimetry methodsWe will perform a pilot study involvingpatients to demonstrate feasibility of recruitingimagingand performing the treatment planningvalidate the reproducibility catheter placementadd and verify quantitative Tcm MAA SPECT CT reconstruction capabilityverify that AD to normal treated liver estimated from Tcm MAA predicts the normal liver AD measured using quantitative Ybremsstrahlung SPECTvalidate automated segmentation of liver in Tcm MAA SPECT CT imagesdevelop and validate a proof of principle cloud based software serviceand obtain approval for the Phase II project s dose escalation trial

* Information listed above is at the time of submission. *

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