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An End-To-End Microfluidic Platform for Engineering Life Supporting Microbes in Space Exploration Missions

Award Information
Agency: National Aeronautics and Space Administration
Branch: N/A
Contract: 80NSSC19C0069
Agency Tracking Number: 140049
Amount: $749,975.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: T6
Solicitation Number: STTR_19_P2S
Timeline
Solicitation Year: 2019
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-07-21
Award End Date (Contract End Date): 2021-07-20
Small Business Information
820 Heinz Avenue
Berkeley, CA 94710-2753
United States
DUNS: 968226634
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: Yes
Principal Investigator
 Erik Jensen
 (925) 766-3997
 e.jensen@hjsciencetech.com
Business Contact
 Hong Jiao
Phone: (408) 464-3873
Email: h.jiao@hjsciencetech.com
Research Institution
 Lawrence Berkeley National Laboratory
 
1 CYCLOTRON RD,
Berkeley, CA 00000-0000
United States

 Federally funded R&D center (FFRDC)
Abstract

HJ ScienceTechnology (HJST) and Lawrence Berkeley National Laboratory (LBNL) propose a highly integrated, programmable, and miniaturized microfluidic automation platform capable of running rapid and complex synthetic biology and bioengineering processes for engineering life supporting microbes in space exploration missions. Our approach combines the microfluidic automation technology of HJST with the novel synthetic biology technologies of 1) combinatorial gene library generation, 2) host transformation, and 3) gene product screening at LBNL and the Joint BioEnergy Institute (JBEI). In Phase I, we have established the feasibility of the proposed microfluidic automation technology by engineering and screening cyanobacterial cells for enhanced production of free fatty acids.In Phase II, we will expand the Phase I microfluidic automation capability to enable automated, metabolic engineering and screening of microbes for enhanced production of other classes of important compounds for in situ resource utilization in NASA space exploration missions:propellant fuels, biopolymers, and pharmaceuticals. We will also build and deliver a Phase II prototype. The successful development of the microfluidic automation technology with its automated and miniaturized platform will lay the groundwork for life supporting waste management and in situ resource utilization capabilities in future NASA manned space exploration missions.

* Information listed above is at the time of submission. *

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