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A Better Mechanism for Controlled Nanopore Translocation

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43HG010527-01
Agency Tracking Number: R43HG010527
Amount: $280,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: 172
Solicitation Number: HG18-003
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-05-01
Award End Date (Contract End Date): 2020-04-30
Small Business Information
San Diego, CA 92121-4206
United States
DUNS: 129852864
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (801) 428-7300
Business Contact
Phone: (858) 412-1800
Research Institution

Project Summary Enabling high accuracy nanopore based strand sequencing has the potential to improve the understanding of long range genomic relationships and processes andbased on its accessibilityenable the associated clinical and diagnostic applicationsthe fastest growing sequencing sectorUnfortunatelyit is commonplace for nanopore sequencing error rates to exceedand higher accuracy is needed to advance nanopore sequencing applications toward assay specific applicationsAmong the various DNA sequencing technologiesnanopore strand sequencing has emerged as a very promising method to enable genomicstranscriptomicsepigenomicsand epitranscriptomics due to the currently associated advantagessuch as adaptabilitycostdirect read capabilitiesread lengthetcrelative to presently market dominating sequencing by synthesis technologiesHoweverthe library preparation procedures associated with nanopore based strand sequencing approachesalong with the resulting read accuracymust be improved before it will be widely adopted and standardized technology in the fieldThusto address the improvements needed to enable high accuracy nanopore based strand sequencingEBS proposes to develop broadly applicable methodology that will vastly improve both library preparation processes and the ability to control strand translocationwhich will provide significantly higher quality sequencing accuracy such that it will yield a nanopore based technology that can be confidently used for clinical or POC use Project Narrative Developing tools that enable improved genomic sequencingvia both both high accuracy and long read capabilitieshas the potential to advance clinical care via the associated diagnostic developmentsSuch achievements will enable routine genomic and precision medicine for comprehensivepersonalized patient screeningwhich in turn will lead to substantial improvements in population healthcare and survival

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