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3D Printed Multifunctional Brain Windows for Simultaneous Optical Imaging and Electrophysiology

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R42NS110165-01A1
Agency Tracking Number: R42NS110165
Amount: $224,759.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: 102
Solicitation Number: PA18-870
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-09-01
Award End Date (Contract End Date): 2020-08-31
Small Business Information
Loretto, MN 55357-9536
United States
DUNS: 080808144
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (612) 301-1636
Business Contact
Phone: (612) 470-9532
Research Institution
MINNEAPOLIS, MN 55455-0149
United States

 Nonprofit college or university

PROJECT SUMMARY This proposal responds to PARtitledBRAIN InitiativeDevelopment Optimizationand Validation of Novel Tools and Technologies for Neuroscience ResearchSTTRThis project is a Fast Track STTR with a phase I and phase IIThe small businessApplied Universal Dynamics CorpAUDis collaborating with the University of MinnesotaU of MNThe activity patterns of tens of millions of neuronsall organized into circuits distributed across multiple brain regions mediate our interaction with the outside worldA mechanistic understanding of the neuronal underpinnings of sensory perceptionactionemotionand cognition requires measuring activities of these neuronal circuits at single cell resolution across several millimetersand at multiple temporal scales temporal scalesWe propose to engineer and commercially disseminate transparent polymer skulls that simultaneously allow wide field optical neural sensing along with high temporal resolution electrical recordings from the whole mammalian cortexWe will build on key technologies developed in in our laboratoriesSpecificallyour collaborative has developed a methodology to design and fabricate transparent skullsBrain Windowsthat allow sub cellular resolution imaging of structure and function of the whole dorsal cortex in behaving miceIn PHASE I of this proposalwe will first utilizedimensional printing methodologies to functionalize these transparent skulls withchannels of transparent electrocorticogramECoGrecording electrodesAimThese devices will be utilized to perform simultaneous mesoscale calcium imaging and ECoG recordingsAimIn PHASE II of this proposalwe will refine theD printing methodology to realize ultra high densitytransparentchannelECoG arraysAimfor simultaneous whole cortex ECoG and cellular resolution calcium imagingAimFinallywe will engineer versions of the technology that allow simultaneous extracellular recordings with surface ECoG and whole cortex optical imaging to realize a platform that allows trueD brain activity mappingAimWe propose to develop and commercially disseminate digitally generatedfunctionalized cranial prostheses`brain windowsandaposthat synergistically combine wide field optical imaging with concurrent electrical recordings of neuronal activities for widefield activity mapping of the whole cortex during behaviorThese developments will lead to fundamentally new experimental paradigms in mice and enable new insights into the neuronal computations that underlie sensory perceptionaction and cognitive processes

* Information listed above is at the time of submission. *

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