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A Mobile Tai Chi Platform for Fall Prevention in Older Adults

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 4R42AG059491-02
Agency Tracking Number: R42AG059491
Amount: $2,389,223.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: NIA
Solicitation Number: PA18-591
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-09-15
Award End Date (Contract End Date): 2022-08-31
Small Business Information
165 PLEASANT ST APT 302
Cambridge, MA 02139-4654
United States
DUNS: 802270988
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 PAOLO BONATO
 (617) 952-6319
 pbonato@partners.org
Business Contact
 ASHKAN VAZIRI
Phone: (888) 589-6213
Email: ashkan.vaziri@biosensics.com
Research Institution
 BRIGHAM AND WOMEN'S HOSPITAL
 
75 FRANCIS STREET
BOSTON, MA 02115-6110
United States

 Domestic Nonprofit Research Organization
Abstract

Project Summary
Exercise-based interventions have been recently shown to have great potential for preserving and restoring
cognitive function in older adults. In this context, Tai Chi has gained the interest of researchers and clinicians
because it incorporates physical, cognitive, social, and meditative components within the same activity. Such
multimodal exercise modality is expected to have a positive effect on older adults’ executive and global cognitive
function, including attentional control, planning, response to inhibition, and working memory. Hence, Tai Chi-
based interventions could help researchers and clinicians to address cognitive decline and dementia in older
adults. In the proposed study, we will recruit a small cohort of older adults, 65-85 years of age, with mild cognitive
impairments, and ask them to participate in a 12-week home-based Tai Chi program. The study will rely on a
tele-health system that our team recently developed as part of the parent award (#R42AG059491). Subjects will
be evaluated pre- and post-intervention using a battery of tests chosen to assess the impact of the intervention
on executive and global cognitive function, physical function, and quality of life. This battery of tests will include,
as primary outcome measures, the Trail Making Test (to assess the impact of the tele-Tai Chi intervention on
cognitive function) and the Dual task Stride Time Variability (DSTV) test (to assess the impact of the tele-Tai Chi
intervention on combined physical and cognitive function). In addition, this battery of tests will include, as
secondary outcome measures, standard assessments of physical function such as the Timed Up-and-Go test,
handgrip strength, the Physical Activity Scale for the Elderly, and the Activities Specific Balance Confidence
(ABC) questionnaire. Health-related quality-of-life will be assessed using the SF-12. Depressive symptoms will
be assessed with the Center of Epidemiology Studies-Depression Scale Revised. Self-reported functional
capacity will be assessed with the Instrumental Activities of Daily Living. These data will be compared pre- vs.
post-intervention to derive effect size estimates and power a future, larger scale study.Project Narrative
There is a growing interest for the development and assessment of exercise-based interventions to slow the
progression of age-related cognitive decline and dementia. Recent literature suggests that Tai Chi provides an
exercise modality that is particularly suitable to preserve and restore executive function, including important
cognitive skills such as attentional control, planning, response to inhibition, and working memory. The
proposed pilot study is meant to provide a preliminary assessment of the effects on older adults with mild
cognitive impairments of a Tai Chi-based exercise program delivered in the home setting using a tele-health
system.

* Information listed above is at the time of submission. *

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