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An Innovative Platform for Objective Monitoring of Instrumental Activities of Daily Living

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 4R42AG060853-02
Agency Tracking Number: R42AG060853
Amount: $3,999,984.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: NIA
Solicitation Number: PAR18-326
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-09-01
Award End Date (Contract End Date): 2021-05-31
Small Business Information
165 PLEASANT ST APT 302
Cambridge, MA 02139-4654
United States
DUNS: 802270988
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 BIJAN NAJAFI
 (847) 578-8456
 bijan.najafi@bcm.edu
Business Contact
 NEDA MOVAGHAR
Phone: (888) 589-6213
Email: neda.movaghar@biosensics.com
Research Institution
 BAYLOR COLLEGE OF MEDICINE
 
1 BAYLOR PLAZA
HOUSTON, TX 77030-3411
United States

 Nonprofit College or University
Abstract

With a Phase I/II STTR grant award from NIA, BioSensics in collaboration with Baylor College of Medicine
(BCM) successfully developed and commercialized an advanced physical activity monitoring system
(PAMSys™) for older adults. PAMSys enables continuous remote monitoring of physical activity, fall risk, and
fall incidents. The fall detection technology of PAMSys has become the gold standard in the medical alert
industry through multiple licensing agreements. To date, more than 100,000 medical alert devices with
BioSensics technology have been sold by our licensing partners. However, PAMSys is not capable of
monitoring Instrumental Activities of Daily Living (IADL) such as cooking, shopping, and managing medication.
Monitoring IADL is essential for timely diagnosis of dementia, monitoring disease progression, and determining
when additional care services are needed. In one of our pilot clinical studies using PAMSys, we identified
specific activity patterns (e.g., transitions between different postures, short walking bouts) in individuals with
cognitive impairment who were monitored during activities of daily living. In addition, BioSensics has developed
an initial prototype of a smart wireless device, called CliQ, that enables interactions with objects at home, while
also simplifying the user interaction with smart home devices and smartphone apps.
Armed with this technical expertise and pilot clinical data, we propose to design and commercialize a platform
for continuous monitoring of IADL. This innovative solution, called IADLSys™, is based on the following three
technologies that will work collectively to provide crucial insight into deterioration in cognitive status and
trajectory toward loss of independence: 1) wireless tags that are attached to various objects of interest in the
user’s living environment, 2) a wearable sensor that measures physical activity, as well as proximity to the
wireless tags, and 3) software that unobtrusively monitors the usage of applications associated with daily
functioning and social engagement to provide a picture of the user’s virtual IADL to complement the monitoring
of their physical IADL (usage time only, no private application data is monitored). IADLSys also includes a hub
to transfer all data to a secure backend server that will be used for data storage and processing.
In Phase I, we will design an initial version of IADLSys and examine the feasibility of the proposed platform for
identifying IADL of interest, including using a telephone, preparing a meal, doing laundry, taking medication,
vacuuming, and others in the target population. In Phase II, we will complete the development of IADLSys
including implementation of live uploading protocols and the cloud-computing backend to host collected data. A
robust data-security architecture will be implemented to protect patient’s privacy. In addition, we will carry out a
clinical study to evaluate if the data gathered and analyzed by IADLSys can discriminate those with Mild
Neurocognitive Disorder (previously termed Mild Cognitive Impairment), and Major Neurocognitive Disorder
due to Alzheimer’s Disease (AD) with mild severity, from cognitively intact aged matched healthy individuals.Assessment of Instrumental Activities of Daily Living (IADL) including cooking, shopping, and managing
medication is essential for timely diagnosis of dementia, monitoring disease progression, and determining
when additional care services are needed. Typically, IADL assessments are subjective, only done at initial
diagnosis, and rarely performed remotely. This grant application proposes the design and commercialization of
a robust platform for objective and continuous remote monitoring of IADL in older adults at risk for dementia or
Alzheimer’s disease.

* Information listed above is at the time of submission. *

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