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Biphase Extended Release Tablet Formulation for Nerve Agent Pretreatment

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911QY-19-C-0010
Agency Tracking Number: C181-004-0040
Amount: $149,967.27
Phase: Phase I
Program: SBIR
Solicitation Topic Code: CBD181-004
Solicitation Number: 18.1
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2018-10-15
Award End Date (Contract End Date): 2019-04-14
Small Business Information
104 T.W. Alexander Dr. Bldg 5 STE 505 P.O. Box 12072
Durham, NC 27709
United States
DUNS: 080123728
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: Yes
Principal Investigator
 Jason Zhou
 (919) 443-9421
Business Contact
 Jason Zhou
Phone: (919) 748-3319
Research Institution

Nerve agents exert their toxic effect by binding to and inactivating enzyme acetylcholinesterase, a key enzymatic regulator of cholinergic neurotransmission. The binding becomes irreversible after a varying amount of time with nerve agents and this aging process limits the treatment window of oxime reactivators. To enhance the current antidote treatment of nerve agent autoinjectors, a pyridostigmine pretreatment with 30-mg tablets of pyridostigmine bromide is authorized to use in a potential nerve agent exposure to soldiers. Pyridostigmine reversibly bind and inhibit a critical number of acetylcholinesterase, protecting them from the irreversible inhibition by Soman. However the approved 30-mg PB tablet is only effective for less than 8 hours and soldiers are required to take the medicine three times a day. In an effort to reduce logistic burdens and improve medication compliance, Zymeron proposes to develop an extended release tablet that can sustain the drug levels in the blood for 24 hours allowing once daily administration. The novel formulation is also thermally stable and resistant to moisture so that it has prolonged shelf-life when stored under ambient conditions.

* Information listed above is at the time of submission. *

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