Real-Time Stress Biomarker Sensor

Research is currently identifying new biochemical markers to help monitor cognition and stress in the human body and enhance human performance. Traditional biometric markers like heart rate, temperature, oxygen partial pressure, blood glucose, electrolyte concentration, and others have been correlated with cognition and stress states. However, the correlation is indirect. Molecular biomarkers with stronger and more specific links are preferred. Molecular biomarkers can be more specific to cognition states and typically take the form of bioactive molecules, with relevant stress-related examples such as Neuropeptide-Y, DHEA-sulfate, and Cortisol. The tools and methods available to quantify molecular biomarkers are sensitive and selective, but also have significant drawbacks. In particular, these tools are inconvenient in a variety of ways that prohibit rapid and comprehensive monitoring and analysis of situational stress response. As researchers identify new biomarkers and sensing mechanisms of importance, there is a need for integrated sensor systems to take full advantage of the spectrum of biomarker detection, enabling accurate biochemical evaluation of physiological stress response. CRG proposes to develop a multi-marker biosensor platform to provide rapid on-site analysis of stress-related biomarkers to assist in cognitive stress response assessment.