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Paper Spray Mass Spectrometry Cartridges with Integrated Sampling and Enrichment

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911SR-19-C-0019
Agency Tracking Number: A18B-020-0137
Amount: $149,955.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: A18B-T020
Solicitation Number: 18.B
Timeline
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2019-02-23
Award End Date (Contract End Date): 2019-02-23
Small Business Information
737 Concord Avenue
Cambridge, MA 02138
United States
DUNS: 557201394
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Piercen Oliver
 Director of Research & Development
 (617) 621-8500
 poliver@nanoterra.com
Business Contact
 Peter Howe
Phone: (617) 621-8500
Email: phowe@nanoterra.com
Research Institution
 Tufts University
 Katie McGeary Katie McGeary
 
136 Harrison Ave Office of the Vice Provost for Research
Boston, MA 02111
United States

 (617) 627-3436
 Nonprofit college or university
Abstract

PS-MS is a simple and powerful method for rapid ambient sample preparation. However, its simplicity also means separation of undesirable components (particulates and molecular interferents) is not possible. Furthermore, samples must be collected by other means (e.g., dried blood spot cards) and placed on the ticket in liquid form before analysis. Although the technique is sensitive (nanograms to tens of picograms LOD), it does not allow for enriching samples or removing undesirable components (particulates, molecular interferents, or reagents incompatible with mass-spectrometry, such as surfactants). Current designs place too much of a burden on the single substrate for sample collection, enrichment, and release to the analyzer. Often the optimal conditions for concentration and purification of an analyte on a substrate (i.e., the surface hydrophobicity and charge, matrix porosity, analyte solubility, and/or biochemical affinity) are conditions that are essentially opposite of the conditions optimal for solubilization and release of the analyte from the paper spray substrate to the MS analyzer. Nano Terra proposes to work with Dr. Charlie Mace at Tufts University to develop a set of PS-MS cartridges with integrated sampling and analyte enrichment. Two cartridge styles are proposed, one for liquid samples (biological and environmental) and one for aerosol/vapor samples.

* Information listed above is at the time of submission. *

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