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Rapid Portable ID and AST Diagnostic for Infected Wound Infections

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: W81XWH20P0150
Agency Tracking Number: H201-001-0070
Amount: $249,959.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: DHA201-001
Solicitation Number: 20.1
Timeline
Solicitation Year: 2020
Award Year: 2020
Award Start Date (Proposal Award Date): 2020-09-30
Award End Date (Contract End Date): 2021-03-29
Small Business Information
601 Genome Way
Huntsville, AL 35806-1111
United States
DUNS: 964433838
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Paula Kollelle
 (256) 679-8660
 pkoelle321@gmail.com
Business Contact
 Peggy Sammon
Title: Psammon
Phone: (256) 783-4506
Email: psammon@genecapture.com
Research Institution
N/A
Abstract

GeneCapture is proposing to use its rapid CAPTURE assay (Confirm Active Pathogens Through Unamplified RNA Expression) to identify the pathogen(s) in wound infections. The pathogen Infection Diagnostic (ID)test takes place in a disposable cartridge that integrates and automates the sample prep steps and determines the genetic signature of the pathogens present. The assay is based on immobilized stem loop probes that are designed to bind to the pathogenic RNA. Once bound, the captors indicate the presence and concentration of the pathogens as measured by quantitative fluorescence. The assay has been validated for several ESKAPE pathogens. Once the pathogen is identified, our planned fully integrated system will perform a rapid phenotypic Antibiotic Susceptibility Test which will measure labelled pathogen-specific bacterial growth in the presence of specific antibiotics, and controls, in a disposable cartridge. Each test (ID and AST) is expected to report in approximately 30 minutes. A single portable reader instrument is proposed which will accept both the ID and AST disposable cartridges. This enzyme-free protocol is designed to operate in austere environments, does not require cold chain for any of the disposables or consumables, and the reader can be operated by battery power.

* Information listed above is at the time of submission. *

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