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Non-Invasive Monitoring of Changes in Intracranial Pressure Due to Infections in the Central Nervous System

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911QY-20-P-0077
Agency Tracking Number: C192-005-0014
Amount: $167,492.99
Phase: Phase I
Program: SBIR
Solicitation Topic Code: CBD192-005
Solicitation Number: 19.2
Solicitation Year: 2019
Award Year: 2020
Award Start Date (Proposal Award Date): 2020-02-04
Award End Date (Contract End Date): 2020-08-04
Small Business Information
567 Bryson Ave
Palo Alto, CA 94306
United States
DUNS: 116937846
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Yong Jin Lee
 (650) 533-9546
Business Contact
 Soenkyung Pak
Phone: (650) 325-9000
Research Institution

Infections of the central nervous system (CNS) are associated with brain swelling and increased cerebral blood volume, as well as focal cerebral perfusion deficits, variable levels of cerebral blood flow and cerebral vasculitis. The net result is increased intracranial pressure (ICP) along with significant risk of brain tissue herniation and ischemic syndromes. ICP monitoring is critical in the management of CNS infections. While invasive ICP measurements through direct access to the cranium using catheters provide reliable ICP measurements, it involves complicated clinical procedures, restricts patient mobility and risks of infection. The goal of the program is to develop and demonstrate the feasibility of a device that can non-invasively track changes in ICP associated with CNS infections. The proposed device measures the ICP based on high-resolution optical and ultrasound characterization of the carotid and cerebral arteries. The solution will be integrated into ambulatory devices worn on the head and/or around the neck.

* Information listed above is at the time of submission. *

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