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BioSENSE, for identification of allosteric transcription factor biosensors

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911NF-20-C-0005
Agency Tracking Number: A2-7903
Amount: $999,999.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: A18B-T016
Solicitation Number: 18.B
Solicitation Year: 2018
Award Year: 2020
Award Start Date (Proposal Award Date): 2019-11-20
Award End Date (Contract End Date): 2021-11-19
Small Business Information
c/o Energy Biosciences Institute 238 Koshland Hall
Berkeley, CA 94720
United States
DUNS: 079761816
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Zachary Sun
 CEO, Co-Founder
 (646) 725-6686
Business Contact
 Zachary Sun
Phone: (646) 725-6686
Research Institution
 UW Madison
 Yang Du Yang Du
21 N. Park St. Suite 6401
Madison, WI 53715
United States

 (408) 821-7622
 Nonprofit College or University

There is a need to develop affordable and specific biosensors to defend against current and future biological threats. Biological methods of detection have been evolved by nature to detect molecules at the micro-scale with flexible specificity and with downstream effectors. Advances in cell-free technology allow for deployment of biosensors on pH-strip-type paper, an affordable, robust, disposable, and highly portable format for Field use. Synvitrobio and UW Madison are developing BioSENSE, a product built off of cell-free expression to produce allosteric transcription factor (aTF) biosensors to DoD-relevant molecules with turnaround of 2-months or less. BioSENSE combines computational aTF design with high-throughput cell-free expression to rapidly test design iterations for activity. In Phase I, we demonstrated the development and use of BioSENSE to sense model molecules using model and engineered aTF biosensors. In Phase II, we propose scaling BioSENSE to develop biosensors towards 10 DoD-defined molecules of interest across 5 classes (pathogenic markers, environmental pollutants, explosives, human performance markers, and toxins). The identified biosensors can be implemented on paper for deployable detection, or can be used within engineered cells.

* Information listed above is at the time of submission. *

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