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Integration of Living Cells in Nanospring Networks for Multisensory Odor Detector

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911NF-19-P-0013
Agency Tracking Number: A18B-012-0160
Amount: $149,989.56
Phase: Phase I
Program: STTR
Solicitation Topic Code: A18B-T012
Solicitation Number: 18.B
Solicitation Year: 2018
Award Year: 2019
Award Start Date (Proposal Award Date): 2018-12-14
Award End Date (Contract End Date): 2019-06-20
Small Business Information
2003 East Bayshore Road
Redwood City, CA 94063
United States
DUNS: 103403523
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Jay Theodore Cremer
 Chief Scientist
 (650) 474-2750
Business Contact
 Charles Gary
Phone: (650) 474-2750
Research Institution
 Western Kentucky University - Applied Physics Institute
 Prof. Vladimir Dobrokhotov Prof. Vladimir Dobrokhotov
Applied Physics Institute, Western Kentucky University 1906 College Heights Blvd #11077
Bowling Green, KY 42101
United States

 (270) 781-3859
 Nonprofit College or University

In this DoD STTR project, we propose a novel electronic nose based on a hybrid bio-nanomaterial, in which the living cells are structurally and electrically coupled to 3D nanostructures (nanosprings) through utilization of gold nanoparticles functionalized with self-assembled monolayers (SAMs). These types of nanostructures are known as hybrid or mixed-type nanostructures. While semiconductor nanosprings can serve as a good catalytic material, coating of semiconductor nanosprings with a thin layer of metallic nanoparticles, then effectively “activates” the surface of the nanosprings, resulting in facile adsorption of molecules onto their surface. Gold nanoparticles modify the electrical response of the nanosprings and can be functionalized with SAMs using alkyl thiol chemistry. SAMs will create the necessary pre-treatment of nanoparticles for efficient electrical coupling with the yeast cells. Ultimately, each cell will be the source of modulating potential on the nanoscale-sized Schottky contacts, created by gold nanoparticles on the surface of semiconductor nanosprings. Due to the extremely high surface area of the nanosprings, a sub-mm nanospring sensor will be in fact 50 nm thick and almost a square meter of interactive surface area, covered by millions of nanoscale Schottky gates, transferring the signals from living cells, coupled to them through self-assembled monolayers.

* Information listed above is at the time of submission. *

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