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Development of Carbon-Conserving Biosynthetic Systems Co-Utilizing C1 and Biomass Derived Feedstocks

Award Information
Agency: Department of Energy
Branch: ARPA-E
Contract: DE-AR0001515
Agency Tracking Number: 2388-1510
Amount: $256,580.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: 1
Solicitation Number: DE-FOA-0002388
Solicitation Year: 2021
Award Year: 2021
Award Start Date (Proposal Award Date): 2021-08-20
Award End Date (Contract End Date): 2022-05-19
Small Business Information
473 Tan Hall
Berkeley, CA 94720
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: Yes
Principal Investigator
 Harshal Chokhawala
 (530) 220-0541
Business Contact
 Harshal Chokhawala
Phone: (530) 220-0541
Research Institution

Herein, Zymochem, Inc., in partnership with the National Renewable Energy Laboratory
(NREL), proposes to develop carbon- and energy-efficient biocatalysts capable of co-conversion
of C1- and biomass-derived substrates to a high-volume platform fuel and chemical intermediate.
We propose to demonstrate a carbon conserving decoupled growth & production (DGP) process
to enable improved carbon efficiency during the growth phase (using phosphoketolase (PKT)
technology developed by NREL), 100% carbon efficient production of bioproducts (using the PKT
pathway and carbon conserving (C2) technology developed at ZymoChem) during production
phase using a C1 feedstock and biomass-derived sugars. Successful completion of this project will
demonstrate the integration of carbon conserving technologies developed by ZymoChem and
NREL to enable co-conversion of biomass sugars and C1 feedstock to (1) improve carbon
efficiencies beyond current theoretical maxima during growth phase of a bioprocess, (2) achieve
100% carbon efficiencies during the production phase of a bioprocess, and (3) development of an
industrial microbe making > 40 gC product/L of 6HH at > 53 kJ product/L/h productivity. The
resultant technology will achieve Program Objectives to accommodate biological reductant
demand in real-time, enable stoichiometric sugar splitting chemistries, and generate fuel- and
chemical intermediates at or above titers and production rates prescribed by a corresponding
system-level and commercial scale techno-economic analysis (TEA).

* Information listed above is at the time of submission. *

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