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Rapid and Reprogrammable Assay for Multiplexed Gene Detection

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-21-P-0007
Agency Tracking Number: A20B-T022-0306
Amount: $166,431.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: A20B-T022
Solicitation Number: 20.B
Solicitation Year: 2020
Award Year: 2021
Award Start Date (Proposal Award Date): 2021-04-12
Award End Date (Contract End Date): 2021-11-11
Small Business Information
89 Rumford Avenue
Newton, MA 02466-1111
United States
DUNS: 066594979
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Muhit Rana
 (781) 529-0551
Business Contact
 Sarah Bonfanti
Phone: (781) 529-0548
Research Institution
 University of Texas at El Paso
 Irene Holguin
500 W. University Avenue
El Paso, TX 79968-0001
United States

 (915) 747-8683
 Nonprofit College or University

Precise diagnosis of biomarkers can stratify the disease progression. Multi-analyte biomarkers provide high-resolution specificity of the disease complexity. At present, Cytochrome P450 single nucleotide polymorphism (SNP) genes (such as as-CYP2D6 and CYP2C19) linked to the metabolism of 25% of clinically used drugs. Detection of these polymorphic genes are essential for drug metabolism is instrumental in drug therapy as well as clinical settings. Currently available technologies such as as-microarrays and qPCR are not qualified for POC because they are labor-intensive, expensive, time-consuming, and requires a large quantity of cDNA. Besides, these methods are more assessable to single biomarker, and often misleads sensitivity, specificity, and efficacy of disease prognosis. The overall objective of this Phase I work is to develop a compact, cost-effective, and POC assay to detect multiple gene biomarkers in bodily fluid samples. Giner proposes to develop a high performance, compact, label-free, highly sensitive, and specific easy-to-use multiplexed sensor utilizing non-enzymatic hybridization chain reaction and electrochemical technology. In collaboration with the University of Texas at El Paso (UTEP), Giner’s POC assay will detect multiple gene biomarkers (specific to drug metabolism) in exogenously enriched blood samples with high specificity and sensitivity.

* Information listed above is at the time of submission. *

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