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A Biliary Tract-Specific Fluorescence Image-guided Surgery

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41EB032284-01
Agency Tracking Number: R41EB032284
Amount: $256,579.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: NIBIB
Solicitation Number: PA20-265
Timeline
Solicitation Year: 2020
Award Year: 2021
Award Start Date (Proposal Award Date): 2021-09-23
Award End Date (Contract End Date): 2022-09-22
Small Business Information
251 LITTLE FALLS DR
Wilmington, DE 19808-1674
United States
DUNS: 117083255
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 JAEPYEONG CHA
 (202) 476-6426
 jcha2@childrensnational.org
Business Contact
 YOSEPH KIM
Phone: (203) 675-7089
Email: yoseph.kim@optosurgical.com
Research Institution
 CHILDREN'S RESEARCH INSTITUTE
 
111 MICHIGAN AVENUE NW
WASHINGTON, DC 20010-2916
United States

 Domestic Nonprofit Research Organization
Abstract

Abstract
The primary liver cancer including intrahepatic bile duct cancer pose significant global burden of illness
with increasing incidence and mortality in US and around the world. Surgery remains the most effective
form of treatment. However, surgical complication rates for medium to high complexity hepatectomies
persist in 30-40% range even in highly skilled hands and at high volume centers. The critical challenges
appear to be attributable to navigating liver parenchymal dissection, where size of resection surface,
associated with blood loss and missed bile leaks from the liver parenchyma, and prolonged operative
time during dissection pose significant obstacle.In this research, we propose to develop an upgraded laparoscopic imager for deeper biliary-specific
fluorescent imaging using a short-wave infrared (SWIR) sensor and high-definition RGB color vision,
and to test the utility of our multimodal laparoscopic imaging technique in liver surgery throughout
preclinical swine studies. The clear anatomic display of intrahepatic critical structures and functional
physiology will make the hepatic dissection safer and more efficient for any liver resection. The goal of
this 1-year research is to develop and evaluate the novel biliary-specific fluorescence and laparoscopic
vision/display through the following specific aims; Aim1: To develop a formfactor SWIR camera
system for fluorescence image-guided laparoscopy; Aim 2: To validate the usefulness of the
developed new vision platform in preclinical animal studies.Narrative
We propose to examine a tissue-specific fluorescence surgical vision tool that will improve function and
outcome of surgical tasks such as complex liver resection surgery. In this research, we will develop a
novel laparoscopic vision device with multimodal optical imaging techniques and validate that
intraoperative display of unseen anatomic structures can improve the surgical outcomes in preclinical
studies.

* Information listed above is at the time of submission. *

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