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DEVELOPMENT OF APTAMERS TO RECOGNIZE NOD-LIKE RECEPTORS IN ZEBRAFISH

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 75N93021C00055
Agency Tracking Number: 75N93021C00055
Amount: $600,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: 94
Solicitation Number: PHS2021-1
Timeline
Solicitation Year: 2020
Award Year: 2021
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
510 Charmany Drive Suite 57
MADISON, WI 53719-1266
United States
DUNS: 832458363
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 MARY OZERS
 (608) 441-2824
 mozers@proteovista.com
Business Contact
 Mary Ozers
Phone: (608) 441-2824
Email: mozers@proteovista.com
Research Institution
N/A
Abstract

The goal of this project is to develop aptameric detection reagents for six zebrafish NOD-like receptors (NLRs) that recognize PAMPs and DAMPs in innate immune cells. Aptamers are an attractive alternative to antibodies as a high affinity reagent for specific binding and detection of proteins due to their structural diversity and ease of synthesis. The success of this project will yield aptamers for detecting important NLR targets to examine immune responses in the zebrafish model for immunology and infectious disease studies.

* Information listed above is at the time of submission. *

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