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TOPIC 435 - PHYSIOLOGICAL COMPRESSION THERAPY TO AUGMENT LYMPHATIC FUNCTION AND IMPROVE LYMPHEDEMA RESOLUTION.

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 75N91022C00024
Agency Tracking Number: 75N91022C00024
Amount: $400,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: 435
Solicitation Number: PHS-2022-1
Timeline
Solicitation Year: 2021
Award Year: 2022
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1101 COLLIER RD NW, #R3
ATLANTA, GA 30318-8211
United States
DUNS: 079568195
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 MICHAEL WEILER
 (703) 505-7720
 mike@lymphatechnology.com
Business Contact
 NATHAN FRANK
Phone: (770) 316-8752
Email: nate@lymphatechnology.com
Research Institution
N/A
Abstract

LymphaTech seeks to develop a novel lymphatic physiology-based, feedback-controlled intermittent pneumatic compression (IPC) device for the treatment of secondary lymphedema. While compression therapy has been the primary treatment for lymphedema patients for decades, there have been minimal innovations in approaches that leverage compression therapy. In contrast to this, there have been substantial gains in understanding of lymphatic physiology and lymphedema disease progression that have not been realized into innovative approaches to improve compression for lymphedema. This Phase 1 proposal aims to develop a prototype that drastically improves medical compression therapy through the major innovations: 1) the incorporation of dynamic external pressure waveforms with magnitudes and temporal and spatial frequencies that are optimized to enhance lymphatic contraction of the lymphatic pump; 2) realtime monitoring of tissue bioimpedance using novel flexible, wearable sensors to provide feedback of tissue water content to compression protocols for optimization of compression based on patient activity (e.g. sleeping, standing, sitting); and 3) incorporation of LymphaTech’s proprietary compression garment sizing and limb measurement volume technology to further enhance compression efficacy. Optimizing the delivery of lymphatic physiology-based compression waveforms combined with real-time feedback from embedded sensors is expected to dramatically increase the clinical efficacy of IPC for lymphedema patients.

* Information listed above is at the time of submission. *

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