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Develop and demonstrate a technology for isolation of bacteriophages with enhanced antibiofilm activity

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: W81XWH22C0015
Agency Tracking Number: H2-0656
Amount: $1,099,895.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: DHA20B-003
Solicitation Number: 20.B
Solicitation Year: 2020
Award Year: 2022
Award Start Date (Proposal Award Date): 2022-02-01
Award End Date (Contract End Date): 2024-05-31
Small Business Information
6820 Moquin Dr NW
Huntsville, AL 35806-2900
United States
DUNS: 185169620
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Deborah Ramsey
 (256) 726-4909
Business Contact
 Tanu Singhal
Phone: (256) 361-0799
Research Institution
 San Diego State University
 Dewayne Roach
5500 Campanile Dr
San Diego, CA 92120-9212
United States

 (619) 594-4172
 Nonprofit College or University

The twenty-first century has seen a global rise in bacterial infections exhibiting antimicrobial-resistance (AMR). More than ninety percent of chronic wounds contain microbial biofilms that exhibit AMR, and the bacteria responsible for several of these recalcitrant infections are called ESKAPEE pathogens. Eradicating ESKAPEE pathogenic infections is challenging, but bacteriophage (phage) therapy is emerging as a new tool to combat AMR in biofilms. Phages thrive in nature, but phage isolation and cultivation from environmental samples requires expensive instrumentation and trained operators. In order to streamline the rapid identification and isolation of phages, we propose to develop a microfluidic impedance-based bacteriophage capture and antibiofilm analyzer (MIPACAA). The portable analyzer will use interchangeable, micro-scale biofilms to capture and enrich phages with antibiofilm activity from environmental samples. Proof-of-concept of the MIPACAA base unit was established in Phase I. Phase II research builds on the Phase I results and further optimizes the individual modules of the MIPACAA system by focusing on the development and characterization of a stand-alone integrated instrument prototype for field-use.

* Information listed above is at the time of submission. *

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