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STTR Phase I:Innovative Expandable Dental Sealer

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 2321456
Agency Tracking Number: 2321456
Amount: $274,867.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: BM
Solicitation Number: NSF 23-515
Solicitation Year: 2023
Award Year: 2023
Award Start Date (Proposal Award Date): 2023-10-01
Award End Date (Contract End Date): 2024-09-30
Small Business Information
240 Prospect ave
Hackensack, NJ 07601
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Ali Mohammad Saghiri
 (347) 921-3254
Business Contact
 Ali Mohammad Saghiri
Phone: (347) 921-3254
Research Institution
607 Taylor Road
Piscataway, NJ 08854
United States

 Nonprofit College or University

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is in developing a novel dental sealer technology for root canal treatments for endodontists and general dentists. The complex and inaccessible nature of the root canal system causes 65% of root canal fillings to fail. Expandable dental sealers used during root canal treatments provide an effective solution by filling the gaps in the canal space by preventing leakage, enabling clinicians to perform the procedure with greater ease and accuracy. This project’s commercial impact includes an addressable market of 22.3 million root canal treatments annually. The proposed innovation supports enhanced patient safety, reduced time at the dentists'/endodontists' office and decreased costs for patients, reduced risk of infection and retreatment, and advanced capabilities of clinicians through training._x000D_
This Small Business Technology Transfer (STTR) Phase I project will characterize the expansion and other properties of the patented elastomeric polyurethane sealer (EPS). The project will begin by generating a functionalized and optimized formula of the EPS using additive ingredients. The team will perform in vitro testing to evaluate the material’s physicochemical properties. Finally, the study will establish the in vivo histocompatibility of EPS using animal models and check its cytotoxicity, a key hurdle that must be overcome before clinical evaluation and Food and Drug Administration (FDA) registration. These studies will facilitate the development of an entirely new type of dental sealer._x000D_
This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

* Information listed above is at the time of submission. *

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