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Developing a new aspiration catheter solution for the treatment of large and medium vessel occlusions

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41NS132732-01
Agency Tracking Number: R41NS132732
Amount: $300,527.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: 104
Solicitation Number: PA22-178
Solicitation Year: 2022
Award Year: 2023
Award Start Date (Proposal Award Date): 2023-07-01
Award End Date (Contract End Date): 2024-12-31
Small Business Information
2225 N. Gemini Rd.
Flagstaff, AZ 86001
United States
DUNS: 078877613
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (928) 523-1468
Business Contact
Phone: (928) 814-4085
Research Institution
FLAGSTAFF, AZ 86011-4130
United States

 Nonprofit College or University

Project Summary/Abstract
Stroke is the leading cause of serious long-term disability and accounts for 4.6 million disabled people in the
United States. Stroke-related costs total over $46 billion in the United States each year.1 Of the nearly 800,000
Americans who have a stroke per year, 87% experience ischemic stroke1, of which 49%-86% are attributed to
either large vessel occlusions (LVO) or medium vessel occlusions (MeVOs).2,3 Mechanical thrombectomy, via
a stent retriever or aspiration catheter, is now the standard of care for eligible patients who experience
ischemic stroke.4–6 While mechanical thrombectomy has progressed dramatically over the past few years,
existing aspiration catheter devices suffer from significant limitations. Major challenges to successful treatment
of ischemic stroke include quickly navigating to the clot and fully capturing it in the first pass while avoiding
thrombus breakage and further downstream ischemia. This project has two aims to address existing limitations
of aspiration thrombectomy. The first aim develops, builds, and tests a prototype aspiration catheter with an
adaptive radially expandable tip. This expandable tip is intended to improve clinical outcomes for all patients
treated with mechanical thrombectomy due to its improved access and navigation capabilities and enhanced
first pass effect (FPE). The second aim tests the efficacy of the novel aspiration catheter using an in vitro
model. This project will lead to the development of a device intended to improve safety and efficacy by
alleviating multiple pass attempts, clot fragmentation, and vessel injury. Through these goals, this project has
the potential to improve the clinical outcome of patients who suffer from ischemic stroke by propelling the field
of neuro-interventional treatments forward.

* Information listed above is at the time of submission. *

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