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Advanced optics to unlock large field-of-view multiphoton imaging for neuroscience and beyond

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41MH136563-01
Agency Tracking Number: R41MH136563
Amount: $292,576.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: 101
Solicitation Number: PA22-178
Solicitation Year: 2022
Award Year: 2023
Award Start Date (Proposal Award Date): 2023-09-19
Award End Date (Contract End Date): 2024-12-31
Small Business Information
Santa Barbara, CA 93111-1469
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (919) 966-2349
Business Contact
Phone: (571) 235-7434
Research Institution
SANTA BARBARA, CA 93106-0001
United States

 Nonprofit College or University

Project summary
Currently available optical components limit biomedical imaging. In particular, in neurobiology, standard microscope
components limit the field-of-view and speed of imaging of neuronal activity. Through prior work on BRAIN
Initiative project, we have developed approaches for new optical components that expand the field-of-view 5 to 50
times over standard microscopes, with no loss in resolution, while retaining high imaging speed. In this project,
we will develop three new products to further impact this field, enabling better imaging systems, higher quality
data, and new experiments. The three products are: (Aim 1) a new long working distance air objective with high
resolution, (Aim 2) a high performance scan lens for large field-of-view imaging, and (Aim 3) an angle-doubling
module for large field-of-view imaging with no loss in scan speed. The company will perform the design studies
and development. The company will partner with the university lab to validate and evaluate the products in
state-of-the-art experiments. The results from this project will result in innovative new optical components that
will expand the field-of-view and throughput of imaging systems in neurobiology labs.

* Information listed above is at the time of submission. *

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