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A Bedside Relational Agent to Improve Hematopoietic Cell Transplantation Outcomes in Cancer Patients

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 4R44CA236253-02
Agency Tracking Number: R44CA236253
Amount: $364,580.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: 101
Solicitation Number: PA18-573
Solicitation Year: 2018
Award Year: 2023
Award Start Date (Proposal Award Date): 2023-09-01
Award End Date (Contract End Date): 2026-08-31
Small Business Information
199 California Dr
Millbrae, CA 94030
United States
DUNS: 080567706
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: Yes
Principal Investigator
 (415) 866-6964
Business Contact
Phone: (415) 866-6964
Research Institution

Delirium, a major cause of falls, can occur in as many as 50% of cancer patients undergoing stem celltransplantation, resulting in up to 14 times greater chance of dying. Delirium risk can be mitigated and manyother outcomes of stem cell transplants can be improved through behavioral interventions delivered at thebedside through conversation, imagery, and audio. However, traditional means of delivering theseinterventions are very labor intensive, difficult to quality control, and difficult to cost-effectively scale to manypatients. In this SBIR Fast-Track proposal, we seek to develop a technology-enabled bedside digital relationalagent specifically programmed to enhance the well-being, safety, and outcomes of cancer patients undergoinginpatient stem cell transplantation, by supporting them through protocols in the following eight categories: Dietand Hydration, Physical Exercise, Incentive Spirometry, Orientation, Non-Pharmacological Pain and AnxietyManagement, Psychosocial Support and Staff Communication, Sleep, and Toileting Assistance. We will thenconduct a three-year clinical study, deploying this new intervention to over 200 adult patients across twooncology/hematology units, aiming to observe (compared to a randomized control group) statistically significantreductions in length of stay, incident delirium rate, fall rate, anxiety, depression, and loneliness, with improvedoverall patient satisfaction and rate of immune system recovery post-transplant. This proposal addresses themajor National Cancer Institute portfolio areas of “Technologies for Cancer Control (Behavioral HealthInterventions)” and “Digital Health (Mobile Health and Health Information Technology).”

* Information listed above is at the time of submission. *

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