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Microogranism Screening Using Gel Microdrops

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 AI38093-01,
Agency Tracking Number: 29117
Amount: $100,001.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1995
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
100 Inman Street
Cambridge, MA 02139
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Susan Sullivan
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract

This research will develop a novel, high throughput method for screening and recovering microorganiproducing antibiotics of interest. The combination of One Cell Systems' gel microdrop encapsulationfluorescence activated cell sorting (FACS), forms the basis for an automated, low unit cost screeninapplicability to the pharmaceutical and chemical industries. By embedding microorganisms of interestmicro- environments, individual organisms can be analyzed and screened for activity. Isolation of miexpected to reduce interference from other substances in the sample, making it possible to rapidly drecover small quantities of active compounds. In the hospital setting, antibiotic resistant Staphylooften fatal, are immune to all but one antibiotic, vancomycin. As well, the reemergence of multi-drutuberculosis isolates, primarily due to the AIDS epidemic, has emphasized the need to develop new, mantibiotics. This research and development program is designed to adapt One Cell Systems, Inc.'s novplatform technology for encapsulating and analyzing single cells to identifying and recovering uniquhaving utility as industrial enzymes or drugs.

* Information listed above is at the time of submission. *

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