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Portable Phage Preparation Technology for Field Application

Award Information
Agency: Department of Defense
Branch: Defense Health Agency
Contract: HT9425-23-C-0052
Agency Tracking Number: A2-9480
Amount: $1,099,900.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: A20B-T023
Solicitation Number: 20.B
Timeline
Solicitation Year: 2020
Award Year: 2023
Award Start Date (Proposal Award Date): 2023-06-29
Award End Date (Contract End Date): 2025-11-02
Small Business Information
6820 Moquin Dr NW
Huntsville, AL 35806-2900
United States
DUNS: 185169620
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Lap Man Lee
 (256) 726-4800
 lapman.lee@cfd-research.com
Business Contact
 Tanu Singhal
Phone: (256) 361-0799
Email: contracts@cfdrc.com
Research Institution
 University of California, San Diego
 Dwayne Roach
 
D5500 Campanile Drive
San Diego, CA 92182-4614
United States

 (619) 594-3066
 Nonprofit College or University
Abstract

Bacteriophages (phages) are becoming important therapeutic candidates against multidrug resistant (MDR) bacterial infections. There is a need to isolate and concentrate phages collected from the field to enhance specimen storage stability for long-distance transport to specialized laboratories for subsequent analysis. Environmental phage preparation requires expensive, bulky instrumentation and intensive manual procedures. In order to streamline the processes for rapid phage enrichment, screening and isolation in the field, we propose to develop a portable system, comprising of microfluidic processing technology for environmental phage preparation. During Phase I, we developed a modular phage sample preparation system which was interconnected with inline microfluidic devices for efficient filtration. We breadboard tested the phage preparation workflow using various simulated environmental samples in the lab. Phase II research will focus on building a miniaturized and ruggedized system for targeted phage propagation and screening. We will extensively test this integrated phage preparation system with environmental samples from the field. Phase III will focus on alpha and beta prototype manufacturing, commercialization and technology validation with the DoD team. Our portable phage preparation of field suspension samples will provide a novel capability in wide usage of both military and civilian applications.

* Information listed above is at the time of submission. *

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