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Protection of Human Skin Against Pesticides

Award Information
Agency: Department of Defense
Branch: Army
Contract: DAAD19-02-C-0047
Agency Tracking Number: A2-0048
Amount: $0.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 2002
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
One Kendall Square, Bldg 600, PMB 299
Cambridge, MA 02139
United States
DUNS: 834374998
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Walid Kuri-Harcuch
 VicePresident of Research
 (617) 679-0029
Business Contact
 Ted Hibben
Title: VicePresident of Business Develop.
Phone: (617) 621-0899
Research Institution

The large area of the human skin and its exposed position on the body surface make it an important portal of entry for toxic agents. Pesticides are able to penetrate the skin and reach the systemic blood and other tissue. Pericor Science has developed atechnology by means of which a pesticide-degrading enzyme can be coupled to the cornified layer of the human epidermis by covalent bonds introduced by a (physiological) transglutaminase-catalyzed reaction. The pesticide-degrading enzyme, when coupled tothe cornified layer, remains active and able to degrade the toxic compound. It is proposed to apply the Pericor method of coupling to protection against pesticides. All aspects of the process relevant to achieving optimum protection will be examined. Testsin vitro and on animals will be used to establish the quality of protection. At the end of the period of the contract, the procedure should be ready for human testing. Anticipated Benefits: The human pesticide protection product being developed underthis STTR Phase II project is a topical prophylactic, probably in "lotion" form, for a multi-day protection against accidental and incidental exposure to organophosphorous-class pesticides. Pericor Science's proprietary corneocyte-linking technology willbe hybridized to an optimized pesticide-neutralizing enzyme developed in conjunction with the Army.

* Information listed above is at the time of submission. *

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