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Respiratory Function Measurement System for Nonhuman Primates

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W81XWH-07-C-0064
Agency Tracking Number: C071-112-0007
Amount: $99,987.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: CBD07-112
Solicitation Number: 2007.1
Solicitation Year: 2007
Award Year: 2007
Award Start Date (Proposal Award Date): 2007-05-10
Award End Date (Contract End Date): 2007-11-09
Small Business Information
Photonic Systems Division 20600 Gramercy Place, Bldg 100
Torrance, CA 90501
United States
DUNS: 153865951
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 Anna Asanbaeva
 Research Scientist
 (310) 320-3088
Business Contact
 Gordon Drew
Title: Chief Financial Officer
Phone: (310) 320-3088
Research Institution

To address the CBD need for a real-time measurement system for nonhuman primate and rabbit respiratory tidal volumes suitable for a Class 3 biological safety (BSL-3) cabinet, Physical Optics Corporation (POC) proposes to develop a new Respiratory Function Measurement (RFM) system. This system is based on a piezoelectric transducer that responds to pressure generated by the animal’s thoracic cage during respiration. The innovative system architecture, with an accurately positioned piezoelectric transducer, wireless data transmission, and materials compatible with formaldehyde and hydrogen peroxide gases, will enable the RFM system to accurately measure, the respiratory parameters of animals during aerosol exposure inside a BSL-3 cabinet and display the data on a PC outside the cabinet in real time. In Phase I POC will demonstrate the feasibility of a RFM system by developing a design and concept for real-time output of tidal volume, respiration frequency, and minute volume; evaluating its suitability for formaldehyde and hydrogen peroxide gas decontamination; and showing its functionality in a BSL-3 cabinet through testing of a system prototype. In Phase II POC will develop a fully functional engineering prototype and test it before and after decontamination.

* Information listed above is at the time of submission. *

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