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Combined Dielectrophoretic Microfluidic System

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W911NF-08-C-0045
Agency Tracking Number: C081-101-0001
Amount: $99,986.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: CBD08-101
Solicitation Number: 2008.1
Solicitation Year: 2008
Award Year: 2008
Award Start Date (Proposal Award Date): 2008-04-18
Award End Date (Contract End Date): 2008-10-18
Small Business Information
Photonic Systems Division 20600 Gramercy Place, Bldg 100
Torrance, CA 90501
United States
DUNS: 153865951
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 Gregory Zeltser
 Principal Scientist
 (310) 320-3088
Business Contact
 Gordon Drew
Title: Chief Financial Officer
Phone: (310) 320-3088
Research Institution

To address the U.S. Army CBD need for a high resolution system whereby proteins present in a complex mixture can be rapidly and reproducibly separated, Physical Optics Corporation (POC) proposes to develop a new Combined Dielectrophoretic Microfluidic (CDM) System based on the integration of electrodeless dielectrophoresis and dynamic isoelectric focusing techniques, used to carry out two-dimensional protein separation inside a microfluidic chip. The CDM system will be composed of a microfluidic chip, AC and DC power supplies, miniature syringe pump, readout unit, and computer. The CDM system will rapidly (7-8 min.), and with high resolution and reproducibility, separate proteins from a complex mixture, such as human cell homogenate. The CDM system will be an inexpensive, portable, and easy to use automated instrument. In Phase I, POC will demonstrate the feasibility of the CDM device by fabricating a prototype, and demonstrating its capability with all the individual proteins from a fairly simple mixture, in a rapid (<10 min.) and reproducible manner. In Phase II, CDM will rapidly (<10 min.) separate biologically relevant proteins in the molecular weight range of 16-200 Kd, and pI range of 3-12, from a complex mixture, such as human cell homogenate, in a reproducible manner.

* Information listed above is at the time of submission. *

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