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Smart Holmium Laser for Endoscopic Lithotripsy

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 DK48578-1,
Agency Tracking Number: 25038
Amount: $80,147.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 1994
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
20 New England Business Center
Andover, MA 01810
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 David Rosen
 (508) 689-0003
Business Contact
Phone: () -
Research Institution

An optical feedback control system for the pulsed holmium: YAG surgical laser will be developedto enhance its safety for endoscopic lithotripsy. The system will enable rapid, intrapulse discriminationof, and selective energy delivery to, calculi versus surrounding soft tissue. This technological advancewill significantly reduce the risk of laser-induced tissue damage during lithotripsies performed with theholmium laser -- a clinical application for which this laser is soon expected to receive FDA approval.Phase I has several objectives: 1) record the time-dependent, spectrally-resolved optical emissionsinduced by pulsed holmium laser irradiation of calculi, urinary tract tissue, urine, blood, etc.; 2) use theseemission data to develop an algorithm for detecting, early in a pulse, whether the laser is beingdischarged on a calculus; and 3) assemble and demonstrate a breadboard opto-electronic control modulewhich will use the developed algorithm to rapidly terminate the laser pulse if the delivery fiber is nottargeted on a calculus, thus limiting the exposure risk to healthy tissue. Completion of these Phase Itasks will demonstrate the technical feasibility of the "smart" holmium laser and lay the necessaryfoundation for subsequent Phase II development efforts.

* Information listed above is at the time of submission. *

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