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Near-infrared Diffuse Optical Imaging for Noninvasive Monitoring of Cortical Spreading Depression

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-06-C-0408
Agency Tracking Number: A064-028-0229
Amount: $99,904.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: A06-T028
Solicitation Number: N/A
Solicitation Year: 2006
Award Year: 2006
Award Start Date (Proposal Award Date): 2006-09-11
Award End Date (Contract End Date): 2007-08-10
Small Business Information
20 New England Business Center
Andover, MA 01810
United States
DUNS: 073800062
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Chad Bigelow
 (978) 689-0003
Business Contact
 B. Green
Title: President, PSI R&D Operations
Phone: (978) 689-0003
Research Institution
 Barbara Steele
50 Staniford Street
Boston, MA 02114
United States

 (617) 724-2725
 Domestic Nonprofit Research Organization

Cortical spreading depression (CSD) is a region of transient electrical and metabolic failure that propagates through peri-lesional brain tissue. Although characteristics of CSD have been shown to be relevant to injury outcome, subdural electrode measurements currently in use restrict monitoring only to patients requiring craniotomy. A portable, noninvasive monitoring device applicable to all patients experiencing CSD would therefore be of great clinical utility from the standpoint of furthering our basic understanding as well as guiding treatment strategies. Ultimately, the device will have broad utility across military and civilian populations for real-time monitoring of a wide variety of events ranging from penetrating brain injury to stroke and migraine. Physical Sciences, Inc. and Massachusetts General Hospital propose to develop a near-infrared spectroscopic device to monitor CSD noninvasively and with minimal interference with routine patient care. The device will produce real-time, 2-dimensional images of cerebral blood flow changes by spatial localization of the absorption coefficients of oxy- and deoxyhemoglobin. Phase I studies will determine the feasibility of the technique for monitoring CSD in a piglet model. In Phase II, a prototype device will be developed that is compact, robust, and suitable for field deployment.

* Information listed above is at the time of submission. *

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