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A Novel Microfludic Device for Drug Toxicity Studies

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: HDTRA1-10-P-0039
Agency Tracking Number: C101-103-0045
Amount: $99,975.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: CBD10-103
Solicitation Number: 2010.1
Solicitation Year: 2010
Award Year: 2010
Award Start Date (Proposal Award Date): 2010-05-17
Award End Date (Contract End Date): 2010-11-16
Small Business Information
215 Wynn Dr., 5th Floor
Huntsville, AL 35805
United States
DUNS: 185169620
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 Balabhaskar Prabhakarpandian
 Principal Scientist
 (256) 327-0665
Business Contact
 Deborah Phipps
Title: Senior Contracts Specialist
Phone: (256) 726-4884
Research Institution

Current drug discovery and development programs are severely limited by the expensive animal trials and oversimplified in vitro models. Results obtained from the in vitro models are not predictive of in vivo toxicity owing to significant difference in testing from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device for quantitative prediction of the toxicity of the drug agent. This device while accelerating the drug screening development process will also reduce animal trials significantly. Our device accurately reproduces the physiological conditions (morphology, flow and cellular make-up) comprising of the respective cells from the targeted organ of interest. Phase I effort will focus on proof of concept studies using liver cells (hepatocytes) as model for toxicity analysis. In Phase II, the device will be extended to include cells from other targeted organs of interest. Animal experiments will be performed to validate the in vitro model. A high throughput device will be developed by integrating the developed prototype with microwell plates.

* Information listed above is at the time of submission. *

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