You are here

RAMAN DETECTION OF HUMAN MACULAR CAROTENOID PIGMENTS

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: PHS2001-2
Agency Tracking Number: 2R42EY012324-02
Amount: $0.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2001
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
175 W 2950 S SALT LAKE CITY, UT 84115-3433
SALT LAKE CITY, UT 84115
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 WERNER GELLERMANN
 (801) 581-5222
 WERNER@PHYSICS.UTAH.EDU
Business Contact
Phone: (801) 467-3391
Email: LASER@NATIONALLASER.COM
Research Institution
N/A
Abstract

DESCRIPTION: The goal of this project is to develop a novel, non-invasive
laser-optical technology for early diagnosis of age-related macular
degeneration (AMD), the leading cause of blindness in the elderly in the United
States. The proposed development of a compact, low-cost diagnostic apparatus
could ultimately provide the ophthalmologic and optometric communities with a
powerful new screening test for AMD risk. The new technology uses Raman
spectroscopy to detect the macular carotenoids lutein and zeaxanthin in the
human retina. Recent basic and clinical science studies have indicated that
these carotenoid compounds play a pivotal role in protecting the human macular
from light-induced oxidative damage. Based on Phase I results, the Raman
technology has the potential to provide a sensitive, fast, quantitative and
objective optical detection of macular carotenoids. We propose to develop the
Raman instrumentation, in the second phase, from an existing apparatus into a
robust device useful for routine use in a clinical setting. Furthermore, we
propose a series of clinical studies in humans to validate its function and to
begin to establish its role as a possible screening test for AMD.
PROPOSED COMMERCIAL APPLICATION:
Screening of macular pigment levels.

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government