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Molecular Signatures of Biological Pathogens

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: DAAD19-02-C-0054
Agency Tracking Number: C021-0070
Amount: $69,412.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 2002
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1539 N. China Lake Blvd, PMB#2
Ridgecrest, CA 93555
United States
DUNS: 111373325
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Guck Ooi
 Chief Scientist
 (760) 447-0681
Business Contact
 Earl Ferguson
Title: CEO
Phone: (760) 371-5088
Research Institution

"The early genomic responses of human peripheral blood mononuclear cells (PBMCs) to in vitro infection with specific microbial pathogens will be assessed by DNA microarray technology. Host gene expression "signature" to microbial pathogen exposure anddistinct host responses will be characterized. Detailed in vitro studies will permit forecasting/predicting expected early molecular markers of in vivo infection with biological warfare agents of high interest with regards to bioterrorism threats (Centersfor Disease Control and Prevention [CDC] Category A biological agents). Phase I will evaluate differential immune response of PBMCs to Bacillus cereus, Bacillus subtilis, and Escherichia coli and will validate in vitro studies by evaluating in vivo immuneresponses to Bacillus anthracis vaccinations and Escherichia coli urinary tract infections. Investigation of other pathogens to generate a comprehensive database of human genomic response to various types of Gram-positive and Gram-negative bacteria andviruses will be undertaken in Phase II in a larger group of subjects at multiple sampling times after infection. Our company goals and plans are to develop a biomedical sensor (or sensors), a field kit or other device for rapid detection of earlydifferential immune responses (lymphokines, cytokines, or other serum markers) to specific microbial pathogens. Understanding the human genomic response to specific infections and identification

* Information listed above is at the time of submission. *

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