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IMPROVED REAGENTS FOR SYPHILIS DIAGNOSIS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 7100
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1987
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
10655 Sorrento Valley Road
San Diego, CA 92121
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 ALAN WALFIELD
 (619) 453-4000
Business Contact
Phone: () -
Research Institution
N/A
Abstract

A PROJECT TO DEVELOP A STATE-OF-THE-ART SERODIAGNOSTIC ASSAY FOR SYPHILIS WITH RECOMBINANT TREPONEMA PALLIDUM ANTIGENS IS PROPOSED. THE DEVELOPMENT OF RECOMBINANT DNA-DERIVED REAGENTS WOULD BE OF GREAT BENEFIT TO THE PUBLICHEALTH AGENCIES, CLINICAL LABS, HOSPITAL, AND BLOOD BANKS THAT CONDUCT SERODIAGNOSTIC TESTS FOR SYPHILIS BY IMPROVING ACCURACY AND LOWERING THE COSTS OF TESTING. THE ANTIGENS WOULD BE PROTEINS RELIABLY AND INEXPENSIVELY PRODUCED FROM BACTERIA BEARING CHIMERIC DNA. THEY WOULD READILY LEND THEMSELVES TO INCLUSION IN AUTOMATED DIAGNOSTIC SYSTEMS AND NOSTIC SYSTEMS AND ONE-DAY TESTING IN DOCTORS' OFFICES. SYNTRO CORPORATION PROPOSES TO PURIFY ANTIGENS EXPRESSED BY E. COLI-T. PALLIDUM RECOMBINANT PLASMIDS AND EVALUATE THEM AS SERODIAGNOSTIC REAGENTS IN AN EXPERIMENTAL IMMUNOASSAY SYSTEM. THIS WOULD TEST THE FEASIBILITY OF A RECOMBINANT DNA APPROACH. ADDITIONALLY, IT IS PROPOSED TO EXPLORE WHETHER OR NOT THESE ANTIGENS WOULD BEST BE PROVIDED BY A CHIMERIC-DNA EXPRESSION VECTOR OTHER THAN E. COLI.

* Information listed above is at the time of submission. *

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