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Preservation Of Platelets For Hemostatic And Wound Healing Bandages

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-05-C-0164
Agency Tracking Number: A054-027-0345
Amount: $100,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: A05-T027
Solicitation Number: N/A
Solicitation Year: 2005
Award Year: 2005
Award Start Date (Proposal Award Date): 2005-08-12
Award End Date (Contract End Date): 2006-02-14
Small Business Information
4050 Sorrento Valley Blvd, Suite L
San Diego, CA 92121
United States
DUNS: 129102708
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Andrew Frelinger III
 Research Associate Professor
 (508) 856-6771
Business Contact
 Victor Bronshtein
Title: President & CSO
Phone: (858) 245-9323
Research Institution
 Patricia McNulty
55 Lake Avenue North
Worcester, MA 01655
United States

 (508) 856-2119
 Nonprofit College or University

Major, uncontrolled bleeding as a result of battlefield injuries or civilian trauma often results in death. Controlling this bleeding, and simultaneously providing a suitable matrix and growth factors for wound healing could prevent some of these deaths and speed recovery. Platelets contribute to hemostasis and wound healing by participating in clot generation and the generation of clot promoting enzymes and by releasing beneficial growth factors. The overall goal of this project is to provide a wound dressing that incorporates a dried form of platelets to take advantage of these properties. Drying processes to preserve platelets at ambient temperatuires have advanced, however a significant barrier to the production of high quality dried platelets is the tendency for platelets to become refractory to activation while being prepared for drying and subsequent vitrification. This proposal addresses the means needed to stabilize platelets during isolation and preservation, so that when rehydrated by moisture at the wound site, they respond by normal activation mechanisms with an appropriate level of pro-coagulant activity and growth factor release. A key feature of maintaining the platelets' response to normal activation mechanisms is that it will provide a reservoir of platelet-derived growth factors to be delivered to the wound over time.

* Information listed above is at the time of submission. *

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