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Live Vibrio Cholera as an Oral SIV Vaccine Vector

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 AI37414-01,
Agency Tracking Number: 29110
Amount: $98,824.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 1995
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
61 Moulton Street
Cambridge, MA 02138
United States
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Yichen Lu
 () -
Business Contact
Phone: () -
Research Institution

Vibrio cholera is a human pathogen that colonizes the gut and elicits both mucosal and systemic proresponses. Novel SIV prophylactics will be developed using a genetically attenuated strain of this oSIV vaccines. These new oral vaccines will be evaluated in animals for their immunogenicity. As a coCollaborative Mucosal Immunology Group for AIDS vaccine (CMIG, AI35544), these vaccines will be evalprimates for their immunogenicity and protective efficacy using the SIV primate model. This study widatabases for developing HIV prophylactics and for conducting human trials. Considering the disastropopulation in developing countries in Africa and in Asia, effective and inexpensive oral HIV1 vaccinto stop the AIDS pandemic.

* Information listed above is at the time of submission. *

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