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THERAPEUTIC CORRECTION OF HYPEROPIA WITH EXCIMER PHOTOREFRACTIVE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 19235
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1992
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
3400 Central Expressway
Santa Clara, CA 95051
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 William B Telfair
 (408) 733-2020
Business Contact
Phone: () -
Research Institution
N/A
Abstract

THERAPEUTIC APPLICATIONS OF EXCIMER PHOTOREFRACTIVE KERATECTOMY (PRK) ARE LIMITED BY EPITHELIAL GROWTH MECHANISMS THAT PRODUCE A FLATTENING OF THE CORNEA. THIS PHYSIOLOGICAL HEALING RESPONSE CAN CAUSE A HIGH DEGREE OF HYPEROPIA TO RESULT IN PATIENTS WHO HAVE AVOIDED CORNEAL TRANSPLANTS BY HAVING HAD ANTERIOR CORNEAL SCARS AND IRREGULARITIES REMOVED WITH EXCIMER LASER TREATMENT. PATIENTS MANIFESTING LARGE AMOUNTS OF HYPEROPIC ASTIGMATISM, E.G. FROM EYE SURGERY, COULD BENEFIT FROM EXCIMER PRK ASTIGMATIC TREATMENT, BUT WOULD BE LEFT WITH AN OVERALL HYPEROPIC CORRECTION, DUE TO THE EXCIMER PRK FLATTENING OF THE STEEPER MERIDIAN. CURRENT METHODS OF SCULPTURING THE CORNEA WITH EXCIMER LASERS ARE NOT VERSATILE ENOUGH TO PRODUCE THE COMPLEX TYPES OF ABLATIONS NECESSARY TO STOP FLATTENING FROM EPITHELIAL REGROWTH. SINCE THE REGROWTH FLATTENING IS IN RESPONSE TO EDGES IN THE STROMA, STABLE HYPEROPIC EXCIMER PRK ALSO REQUIRES COMPLEX CONTOURING AT THE EDGE OF THE ABLATION ZONE. WE WILL DEVELOP PROTOTYPE INSTRUMENTATION FOR GENERATING COMPLEX ABLATIONS TO BE USED IN HYPEROPIC EXCIMER PRK PROCEDURES. IT WILL BE TESTED ON PLASTIC TO EVALUATE THE PREDICTABILITY AND RELIABILITY OF THE SYSTEM. ANIMAL STUDIES WILL BE CONDUCTED IN PHASE II.

* Information listed above is at the time of submission. *

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