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TISSUE SLICES FROM TRANSGENIC MICE-TOXICOLOGICAL TOOL

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: PHS2001-2
Agency Tracking Number: 1R41ES010668-01
Amount: $118,873.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2001
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
BOX 12355/2500 N TUCSON BLVD 116 TUCSON, AZ 85732
TUCSON, AZ 85732
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 A GANDOLFI
 (520) 626-6696
 GANDOLFI@PHARMACY.ARIZONA.EDU
Business Contact
Phone: (602) 327-4533
Email: VITRON@VITRON.COM
Research Institution
 UNIVERSITY OF ARIZONA
 
UNIVERSITY OF ARIZONA
TUCSON, AZ 85719
United States

 Nonprofit College or University
Abstract

DESCRIPTION (Adapted from the Investigator's Abstract): The main objective of
this grant proposal is to use precision-cut tissues slices from
genetically-modified mice as an in vitro system for rapid assessment for
potential chemical toxicities. The Phase I goals are to develop two transgenic
mice, one that has an aryl hydrocarbon receptor responsive promoter linked to
green fluorescent protein and another that has an estrogen receptor responsive
promoter linked to yellow fluorescent protein. These mice would facilitate the
development of subsequent in vitro model systems to test the responsiveness of
the constructed promoters to toxic chemicals. After characterization of these
transgenic mice, the PI proposes in Phase II to crossbred these two transgenic
strains containing the aforementioned reporter constructs to generate a
supermouse. Tissues slices from this supermouse can be simultaneously monitored
for a number of toxic events in multiple tissues from a single mouse.
PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

* Information listed above is at the time of submission. *

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