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LOW LEVEL TRACES MAPPING USING MONOCHROMATIC X-RAYS

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 2R44RR014935-02
Agency Tracking Number: RR014935
Amount: $0.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2002
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
X-RAY OPTICAL SYSTEMS, INC. 30 CORPORATE CIR
ALBANY, NY 12203
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 ZEWU CHEN
 (518) 880-1500
 ZCHEN@XOS.COM
Business Contact
 DAVID USHER
Phone: (518) 464-3334
Email: DUSTER@XOS.COM
Research Institution
N/A
Abstract

There are important medical applications that will benefit from a desktop imaging tool which detects and maps parts per billion level metals and other heavy elements in tissues in vitro and in vivo. A compact instrument will be proposed for elemental imaging of dry tissues as well as living tissues based on monochromatic micro x-ray fluorescence (MMXRF). This tool, based on innovative, large-aperture, doubly-curved crystal optics, is capable of detecting ppb levels of transition metal and heavy elements with a spatial resolution of a few micrometers. This would assist in the research of Alzheimer?s and Parkinson?s diseases, prostate cancer and other medical issues. This can also be a relatively inexpensive tool for the screening and monitoring of environmental and occupational exposure of toxic elements. The Phase I research has been very successfully completed and the feasibility of the MMXRF has been clearly demonstrated. In this Phase II project, a prototype desktop MMXRF system will be developed that incorporates an interchangeable modular x-ray beam unit to probe samples with different x-ray energies. Spatial distribution of Mn, Fe, Se, and Cd will be mapped in tissues related to Alzheimer?s disease and prostate cancer using the prototype system.

* Information listed above is at the time of submission. *

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