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Mechanistic Studies of Spore Killing Using Variable Frequency Microwaves

Award Information
Agency: Department of Defense
Branch: Army
Contract: W911NF-05-C-0080
Agency Tracking Number: A054-010-0170
Amount: $100,000.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: A05-T010
Solicitation Number: N/A
Solicitation Year: 2005
Award Year: 2005
Award Start Date (Proposal Award Date): 2005-08-15
Award End Date (Contract End Date): 2006-02-11
Small Business Information
860 Aviation Parkway, Suite 900
Morrisville, NC 27560
United States
DUNS: 867046732
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Howard Reisner
 (919) 966-4265
Business Contact
 Clayton DeCamillis
Title: Director of Engineering
Phone: (919) 462-1919
Research Institution
 Tony G Waldrop
104 Airport Dr., Ste. 2200, OSR, CB# 1350
Chapel Hill, NC 27599
United States

 (919) 966-3411
 Nonprofit College or University

The overall objective of this proposal is to characterize the molecular mechanism by which variable frequency microwave technology (VFM) inactivates bacterial spores. The long-term practical goal is to produce a device capable of eliminating contamination by microbial/viral/biological based biological warfare bioterrorism agents. Considerable scientific uncertainty exists regarding the molecular mechanisms of spore killing by microwaves. Hence, the immediate goal of this project is to study the mechanisms of VFM spore inactivation at the molecular level. To accomplish our objective the kinetics of inactivation of simulant spores derived from B. subtilis will be determined using VFM technology and compared to that of dry heat using a variety of solid surfaces which differ in their absorbance of microwave energy. In addition, the level of applied microwave power will be correlated with kill kinetics. Because DNA damage is a likely target for microwave induced damage, a search will be made for specific mutations in spore DNA. Such mutations are known to correlate with previously characterized modes of spore killing.

* Information listed above is at the time of submission. *

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