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A novel recombinant vaccine against Cryptococcus.

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41AI062482-01
Agency Tracking Number: AI062482
Amount: $99,999.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2004
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
MYCOLOGICS, INC. 12635 E MONTVIEW BLVD, STE 131
AURORA, CO 80010
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 CLAUDE SELITRENNIKOFF
 (720) 859-4190
 CLAUDE.SELITRENNIKOFF@UCHSC.EDU
Business Contact
 CLAUDE SELITRENNIKOFF
Phone: (720) 859-4190
Email: CLAUDE.SELITRENNIKOFF@UCHSC.EDU
Research Institution
 ST. LOUIS UNIVERSITY
 
221 North Grand Boulevard
Aurora, MO 63103
United States

 Nonprofit College or University
Abstract

DESCRIPTION (provided by applicant): Cryptococcus neoformans is an encapsulated pathogenic yeast that causes pulmonary infections and meningoencephalitis in humans and other animals. During the last 20 years, there has been a dramatic increase in the incidence of cryptococcosis throughout the world that mirrors the increase in not only HIV infections, but also in the growing number of immuno compromised patients. Loss of CD4+ T cells predisposes patients to progressive infection with C. neoformans--this emphasizes the role of cell mediated immunity in host resistance.
Our long-term corporate goals are to discover new drugs for the treatment of fungal diseases and to develop vaccines against a number of human pathogenic fungi. In this Phase I STTR proposal, we plan to develop a safe and effective vaccine against C. neoformans. We will use a novel antigen delivery system and test a number of C. neoformans proteins as vaccine candidates. We will accomplish this in two specific aims:
Specific Aim One: Engineer yeast cells to express each of five C. neoformans proteins using recombinant DNA technology.
Specific Aim Two: Test the in vivo efficacy of each vaccine formulation to protect vaccinated animals against a challenge of C. neoformans.
This work will be a prelude to work in Phase II that will include detailed testing for in vivo efficacy and safety of each vaccine candidate. Ultimately, the Phase I, Phase II and Phase lll research will lead to the development of a vaccine against C. neoformans

* Information listed above is at the time of submission. *

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