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Developmental Biology & Perinatal Medicine Research

Description:

Research in three major program areas includes: pregnancy and Perinatology; developmental biology, genetics and teratology; and mental retardation and developmental disabilities. Topics that may be of interest to small businesses include, but are not limited to, those identified below.

A. Pregnancy and Perinatology. The topic areas of research include the physiology of pregnancy and labor; high-risk pregnancies, including those with hypertensive disorders, diabetes or seizure disorders; fetal pathophysiology; premature labor and birth; diagnostic, monitoring, and therapeutic devices and instruments for newborn infants in the nursery and in Neonatal ICU setting; improving the existing products or developing new products that would improve the routine and extended care of the newborn infants; products and agents related to breastfeeding; hospital supplies specifically related to use in the care of newborn infants; nanotechnology and its application for the care of newborn infants; instruments and devices assessing and monitoring the nursery environment (noise, lighting, and odor); disorders of the newborn; sudden infant death syndrome; and biological and behavioral antecedents of low birth weight.

The following topic areas are of high priority:

? Non-invasive methods for assessing cardiovascular and pulmonary functions, including cardiac output, systemic blood pressure, airway resistance, pulmonary compliance, vital capacity and various lung volumes.

? Metabolic profile assessment using non-invasive or minimally invasive approaches. Particular area of expertise include measurement of glucose and lactate/pyruvate; assessing ketone body measurements; free indirect bilirubin (uncongjugated, free indirect); major chemicals (Na+ Ca + Cl+ K+ etc.) in the blood.

? Improved point of care methods to measure plasma glucose concentrations quickly and accurately.

? Devices, instruments, and tools to minimize bacterial colonization, reduce proclivity for thrombous formation; reduce health-care associated infection risks.

? Rapid methods for diagnosis of bacterial infections and inflammation.

? Non-invasive measures to assess brain energy utilization, especially glucose, oxygen, lactate, ketones, and other energy substrates.

? Innovative ideas to reduce stress for the staff, parents and infants in the NICU.

Dr. Tonse Raju

301-496-5575, Fax: 301-496-3790

Email: rajut@mail.nih.gov

B. Developmental Biology, Genetics, and Teratology. Biomedical research on the cellular, molecular, and genetic aspects of normal and aberrant embryonic and fetal development including early embryogenesis, limb formation, organ and limb regeneration, development of the nervous system, developmental immunology, and causative factors in teratogenesis. Areas of interest included but are not limited to:

? development and application of new animal model systems

? innovative and high throughput genomic and proteomic techniques

? systems biology approaches to advance the study of embryonic development and structural birth defects

? in vivo techniques for optical imaging and quantitative measurement of physical properties of cells/tissues

? innovative technologies for imaging of developmental processes and gene expression

Dr. Lorette Javois

301-496-5541, Fax: 301-480-0303

Email: lj89j@mail.nih.gov

C. Intellectual and Developmental Disabilities. Biomedical, behavioral and biobehavioral research in neuroscience, genetics, biochemistry, molecular biology, and psychobiology aimed at identifying factors that cause abnormal brain maturation and function; identification of direct and indirect environmental factors (e.g., social, economic and cultural) that influence the occurrence of intellectual and developmental disabilities (IDD); and research leading to the prevention, amelioration, assessment and treatment of IDD, including approaches that involve expanded newborn screening and prenatal diagnosis.

Dr. Tiina K. Urv

301-402-7015, Fax: 301-496-3791

Email: urvtiin@mail.nih.gov

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