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Epithelial Cell Regulation and Transformation


Emphasis is on the molecular mechanisms of oral epithelial cell regulation and aberrations of these mechanisms. Research related to early diagnosis, prevention, and treatment of oral neoplasias is particularly relevant for the NIDCR small business program. Some examples include but are not limited to the following areas:

A. Develop imaging techniques for the early detection, diagnosis and prognosis of pre-malignant head and neck lesions including oral salivary gland carcinomas.

B. Develop immunotherapies (e.g. vaccines, gene therapies) effective against viruses suspected to be etiologic agents in the induction of pre-malignant and malignant head and neck lesions.

C. Develop effective pharmacological, immunological and radiological modalities for treatment of pre-malignant and malignant head and neck lesions.

D. Develop novel technologies for the genetic and molecular-targeted therapy of head and neck carcinomas.

E. Develop novel micro and nano-sensor technologies that can release therapeutic agents in tumor cells.

F. Develop regimens for the alleviation of the oral complications of cancer therapy.

G. Develop novel technologies for using stem cells as therapeutics for head and neck cancers

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