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Mineralized Tissue and Salivary Gland Physiology, Pharmacogenetics and Injury

Description:

Emphasis is on the physiology of bones, teeth and salivary glands, craniofacial tissue damage and repair, and pharmacogenetics of agents used for the treatment of craniofacial and oral diseases and disorders. Such technologies that could speed translational research might include but are not limited to:

A. Develop standardized, high-sensitivity, high-accuracy methods, instrumentation, and/or devices to detect oral bone loss, assess alveolar bone quality, and to monitor for bone repair.

B. Develop novel agents and vehicles for local inhibition of bone loss and/or augmentation of bone growth for the treatment of periodontal diseases or craniofacial reconstruction.

C. Develop novel methods and instrumentation to detect and/or treat the earliest signs of demineralized enamel that may develop into carious lesions.

D. Develop systems that effectively remove or neutralize dental caries using non-mechanical means to minimize iatrogenic pulp death.

E. Develop non-invasive devices to assess pulpal health prior to and during treatment; develop means to neutralize necrotic pulps non-mechanically to reduce or eliminate the need for root canal therapy.

F. Develop novel methods and agents to promote scarless repair of cleft lip and scarless cutaneous healing following craniofacial surgery.

G. Develop viral and non-viral vectors for salivary gene therapy and gene therapeutics.

H. Develop non-invasive methods for the determination of efficacy and safety of artificial saliva, sialogogues and of their delivery vehicles used in addressing the diminution or lack of saliva (xerostomia) due to Sj?gren?s syndrome or head and neck irradiation cancer therapy.

I. Develop apparatus for craniofacial bone distraction for building bone for craniofacial reconstruction or orthodontic procedures.

J. Develop more efficient methods, materials, and devices for prevention of injuries to the teeth, mouth, and face during athletic activities.

K. Develop genetic standards, databases, and diagnostics to predict oral responses to drugs used for the treatment of craniofacial, oral and dental diseases.

L. Develop standardized methodologies for the detection of fluoride load in the body from saliva, serum, urine, nail clippings, and hair.

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