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Division of Genetics and Developmental Biology

Description:

Research on developing a better understanding of fundamental processes and mechanisms of development and inheritance in health and disease. Support of basic topics in genetics and developmental biology, including nucleic acid chemistry, the structure of genetic material, the mechanisms of transmission and expression of genetic information, cellular regulation of growth and differentiation, and population genetics. Areas that may be of interest to small businesses include, but are not limited to:

A.     Development of computer software for the analysis of the primary and secondary structures of nucleic acids as these relate to genetic problems.

B.     Improvement in procedures for the separation and analysis of nucleic acids and proteins as these relate to genetic problems.

C.     Improvement of methodology (technology) for genetic analysis (e.g., gene expression, probes).

D.     Development of probes for detection of human genetic polymorphisms, including disease genes.

E.     Development of improved procedures for cytogenetics and diagnostic array technology.

F.     Improvement in procedures (statistical, computational, laboratory) for the analysis of gene flow and gene dynamics in human populations.

G.     Development of improved vectors for gene transfer.

H.     Development of valid animal models for genetic diseases and birth defects.

I.     Development of quantitative approaches to the analysis of complex biological systems.

J.     Development of tools and technologies to detect and monitor complex human phenotypes or traits.

K.     Development of technology to derive and expand pluripotent cell populations from non-embryonic sources, for example, induced pluripotent stem cells (iPS).

L.          Development of improved technology to scale up the growth of induced pluripotent stem cells in culture and to regulate their differentiation state

M.          Development of markers, reagents and tools to characterize the unique properties of iPS cell lines and to distinguish them from adult stem cells and more differentiated cells.

N.     Development of existing human embryonic stem cell lines and new or existing iPS cells as a model system for drug discovery.

O.     Development or improvement of methodology for generation of antibodies or other affinity reagents for proteins and other small molecules in non-mammalian genetic model systems.

P.     Improvement in procedures (statistical, computational, laboratory) for the high- and medium-throughput analysis of gene expression patterns and regulatory networks.

Q.     Development or improvement of methods for high throughput detection of epigenomic changes.

R.     Development or improvement of methods for characterizing the metabolic interactions of complex communities of microorganisms particularly those involved in host-microbe interactions.

S.     Development of improved or novel methodology for structure/function analysis of very large macromolecular complexes involved in transmission or expression of genetic material.

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