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Fatty Acid-Producing Microbes for Generating Medium- and Long-Chain Hydrocarbons


UWMadison GLBRC researchers have developed genetically modified E. coli that are capable of overproducing fatty acid precursors for medium- to long-chain hydrocarbons. The modified bacteria can be used to ferment biomass-derived sugars to fatty acids. These fatty acids can be separated from the fermentation media and subsequently used as feedstock for biofuels and biorenewable chemicals based on medium- and long-chain hydrocarbons. The modified bacteria were transformed with exogenous nucleic acids to increase the production of acyl-ACP or acyl-CoA, reduce the catabolism of fatty acid products and intermediates, and-or reduce feedback inhibition at specific points in the biosynthetic pathway.
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