You are here

Resonant-Photonic-Device-Enhanced SERS Substrate with Pinpointed Plasmonic-Active

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 9R42ES024023-02
Agency Tracking Number: R42ES024023
Amount: $996,938.00
Phase: Phase II
Program: STTR
Solicitation Topic Code: NIEHS
Solicitation Number: PA12-089
Solicitation Year: 2013
Award Year: 2013
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
8500 Shoal Creek Blvd. Blg 4 Suite 200
AUSTIN, TX 78757
United States
DUNS: 102861262
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 (512) 996-8833
Business Contact
Phone: (512) 825-4480
Research Institution
UNIVERSITY OF TEXAS AUSTIN 101 E 27th Street Suite 5.300
AUSTIN, TX 78712-1532
United States

 () -
 Nonprofit College or University

DESCRIPTION (provided by applicant): The use of Surface Enhanced Raman Scattering (SERS) for biomolecule detection has been restricted due to the great difficulty of fabricating ultrasensitive and reproducible surface-plasmonic-resonance (SPR) substrates.Therefore, detecting extremely small amount of biomolecules for clinical application is significantly limited. In this STTR Phase II research, we propose to develop ultrasensitive (1012~1014 enhancement factors) SERS substrates with universally availableRaman hot spots for well-reproducible biomolecule detection by combining optical field enhancements from both resonant photonic devices and metallic nanoentities. Compared with existing SPR substrates made by spin-coating colloidal nanoparticles or nanowire solutions, we engineer the SERS substrate using silica nanotubes coated with universally distributed silver nanoparticles, which can dramatically increase the density of the Raman scattering hot spots . We also employ highly robust Si3N4 guided-mode-resonance (GMR) gratings and resonant microcavity array to achieve even higher local electric field for SERS sensing. To link these two innovations, we will apply a highly exquisite tool---electric tweezers, to assemble the SPR-active nanotubes into the resonant photonic devices with unbeatable spatial precision of at least 150 nm. In our Phase I program, we have theoretically simulated and experimentally demonstrated SPR-active silica nanotubes with nanometer-size gaps, and detected Rhodamine 6G down to 100fM (single-molecule level) with enhancement factors of 1.1x1010. Moreover, we fabricated Si3N4 GMR gratings using state-of-the-art nanofabrication processes and experimentally achieved ~10? enhancement factors in addition to the existing SERS effect fromthe SPR-active silica nanotubes. In the Phase II program, we will continue to optimize the SERS substrates for ultrahigh sensitivity up to 1012~1014 enhancement factors, improve the detection probability of ultralow concentration biomolecules in real biological samples, and apply the SERS substrates in various biomedical applications. Most of all, we will resolve potential technical challenges for product commercialization, including lowering the fabrication cost, increasing the throughput, packaging the SERS substrate with fiber-optic systems and evaluating the device reliability. PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE: Surface Enhanced Raman Scattering (SERS) has significant potential in biomolecule detection due to its extremely high sensitivity in hot spots . However, the average sensitivity, repeatability, and reliability of current SERS techniques cannot meet the requirements of many biomedical applications. This project focuses on the development of SERS substrates with universallyavailable Raman hot spots for ultrasensitive and well- reproducible biomolecule detection through the combination of resonant photonic devices and metallic nanoentities, which has significant potential for early disease detection and personal diagnostics.

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government